{"id":110,"date":"2016-12-05T02:18:01","date_gmt":"2016-12-05T04:18:01","guid":{"rendered":"https:\/\/dnareference.com.br\/?page_id=110"},"modified":"2020-01-10T17:43:46","modified_gmt":"2020-01-10T20:43:46","slug":"cd40-l-e-neutropenia","status":"publish","type":"page","link":"https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/cd40-l-e-neutropenia\/","title":{"rendered":"CD40 L e Neutropenia"},"content":{"rendered":"<p>[et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;Rinite&#8221; fullwidth=&#8221;on&#8221; specialty=&#8221;off&#8221; transparent_background=&#8221;off&#8221; allow_player_pause=&#8221;off&#8221; inner_shadow=&#8221;off&#8221; parallax=&#8221;off&#8221; parallax_method=&#8221;off&#8221; padding_mobile=&#8221;off&#8221; make_fullwidth=&#8221;off&#8221; use_custom_width=&#8221;off&#8221; width_unit=&#8221;on&#8221; make_equal=&#8221;off&#8221; use_custom_gutter=&#8221;off&#8221;][et_pb_fullwidth_post_title admin_label=&#8221;T\u00edtulo da P\u00e1gina de Largura Inteira&#8221; title=&#8221;on&#8221; meta=&#8221;off&#8221; author=&#8221;on&#8221; date=&#8221;on&#8221; categories=&#8221;on&#8221; comments=&#8221;on&#8221; featured_image=&#8221;off&#8221; featured_placement=&#8221;below&#8221; parallax_effect=&#8221;on&#8221; parallax_method=&#8221;on&#8221; text_orientation=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_background=&#8221;off&#8221; text_bg_color=&#8221;rgba(255,255,255,0.9)&#8221; module_bg_color=&#8221;#e02b20&#8243; title_all_caps=&#8221;off&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221; title_font_size=&#8221;30px&#8221; title_font=&#8221;|on|||&#8221; title_text_color=&#8221;#ffffff&#8221;]<br \/>\n[\/et_pb_fullwidth_post_title][\/et_pb_section][et_pb_section bb_built=&#8221;1&#8243; admin_label=&#8221;section&#8221;][et_pb_row admin_label=&#8221;Linha&#8221;][et_pb_column type=&#8221;1_3&#8243;][et_pb_sidebar admin_label=&#8221;Barra Lateral&#8221; orientation=&#8221;left&#8221; area=&#8221;et_pb_widget_area_1&#8243; background_layout=&#8221;light&#8221; remove_border=&#8221;off&#8221;]<br \/>\n[\/et_pb_sidebar][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243;][et_pb_text admin_label=&#8221;O que \u00e9?&#8221; background_layout=&#8221;light&#8221; text_orientation=&#8221;left&#8221; use_border_color=&#8221;off&#8221; border_color=&#8221;#ffffff&#8221; border_style=&#8221;solid&#8221;]<\/p>\n<h3>DEFICI\u00caNCIA DE CD40 LIGANTE E NEUTROPENIA<\/h3>\n<h3>Estudo de caso &#8211; Paulinho<\/h3>\n\n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-1 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 50%;\n\t\t\t}\n\t\t\t#gallery-1 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-1' class='gallery galleryid-110 gallery-columns-2 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/cd40-l-e-neutropenia\/imunodeficiencias_paulinho\/'><img loading=\"lazy\" decoding=\"async\" width=\"243\" height=\"158\" src=\"https:\/\/dnareference.com.br\/clinica\/wp-content\/uploads\/sites\/3\/2016\/12\/Imunodeficiencias_Paulinho.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-464\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-1-464'>\n\t\t\t\tPaulinho passou por transplante de medula e foi curado\n\t\t\t\t<\/dd><\/dl><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/cd40-l-e-neutropenia\/imunodeficiencias_cd40\/'><img loading=\"lazy\" decoding=\"async\" width=\"243\" height=\"158\" src=\"https:\/\/dnareference.com.br\/clinica\/wp-content\/uploads\/sites\/3\/2016\/12\/Imunodeficiencias_CD40.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-463\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-1-463'>\n\t\t\t\tCD40L\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p>Os pacientes com imunodefici\u00eancias prim\u00e1rias sofrem infec\u00e7\u00f5es por\u00a0n\u00e3o possu\u00edrem defesas imunol\u00f3gicas.\u00a0Muitos n\u00e3o produzem anticorpos, como o caso do Paulinho. Ele tinha uma altera\u00e7\u00e3o num gene que n\u00e3o permitia que as c\u00e9lulas produzissem seus anticorpos de defesa IgG e IgA. Logo, estava constantemente com infec\u00e7\u00f5es, o que acarretaria pouca sobrevida. O diagn\u00f3stico foi complexo, necessitando do sequenciamento de seu DNA e posterior transplante de medula \u00f3ssea. A nova medula com suas c\u00e9lulas tronco reconstitu\u00edram as defesas do Paulinho.\u00a0<strong>Paulinho est\u00e1 curado!<\/strong><\/p>\n<p>Os resultados iniciais dos exames eram:<\/p>\n<ul>\n<li>IgG:0<\/li>\n<li>IgA:0<\/li>\n<li>IgM 104<\/li>\n<li>Neutrop\u00eanico severo<\/li>\n<li>Aus\u00eancia c\u00e9lulas maduras na Medula \u00d3ssea<\/li>\n<li>Muta\u00e7\u00e3o no CD40L: (exon 5,A&gt;G)<\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DEFICI\u00caNCIA DE CD40 LIGANTE E NEUTROPENIA Estudo de caso &#8211; Paulinho \n\t\t<style type=\"text\/css\">\n\t\t\t#gallery-2 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-2 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 50%;\n\t\t\t}\n\t\t\t#gallery-2 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-2 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-2' class='gallery galleryid-110 gallery-columns-2 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/cd40-l-e-neutropenia\/imunodeficiencias_paulinho\/'><img width=\"243\" height=\"158\" src=\"https:\/\/dnareference.com.br\/clinica\/wp-content\/uploads\/sites\/3\/2016\/12\/Imunodeficiencias_Paulinho.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-2-464\" decoding=\"async\" loading=\"lazy\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-2-464'>\n\t\t\t\tPaulinho passou por transplante de medula e foi curado\n\t\t\t\t<\/dd><\/dl><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/cd40-l-e-neutropenia\/imunodeficiencias_cd40\/'><img width=\"243\" height=\"158\" src=\"https:\/\/dnareference.com.br\/clinica\/wp-content\/uploads\/sites\/3\/2016\/12\/Imunodeficiencias_CD40.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-2-463\" decoding=\"async\" loading=\"lazy\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-2-463'>\n\t\t\t\tCD40L\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n Os pacientes com imunodefici\u00eancias prim\u00e1rias sofrem infec\u00e7\u00f5es por\u00a0n\u00e3o possu\u00edrem defesas imunol\u00f3gicas.\u00a0Muitos n\u00e3o produzem anticorpos, como o caso do Paulinho. Ele tinha uma altera\u00e7\u00e3o num gene que n\u00e3o permitia que as c\u00e9lulas produzissem seus anticorpos de defesa IgG e IgA. Logo, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":672,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-110","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages\/110"}],"collection":[{"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/comments?post=110"}],"version-history":[{"count":5,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages\/110\/revisions"}],"predecessor-version":[{"id":683,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages\/110\/revisions\/683"}],"up":[{"embeddable":true,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages\/672"}],"wp:attachment":[{"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/media?parent=110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}