{"id":110,"date":"2016-12-05T02:18:01","date_gmt":"2016-12-05T04:18:01","guid":{"rendered":"https:\/\/dnareference.com.br\/?page_id=110"},"modified":"2020-01-10T17:43:46","modified_gmt":"2020-01-10T20:43:46","slug":"cd40-l-e-neutropenia","status":"publish","type":"page","link":"https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/cd40-l-e-neutropenia\/","title":{"rendered":"CD40 L e Neutropenia"},"content":{"rendered":"<p><div class=\"et_d4_element et_pb_section et_pb_section_0  et_pb_css_mix_blend_mode et_pb_fullwidth_section et_section_regular et_block_section\" >\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_fullwidth_post_title_0 et_pb_post_title  et_pb_text_align_center et_pb_bg_layout_light et_pb_image_below\"   >\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_title_container\">\n\t\t\t\t\t<h1 class=\"entry-title\"><\/h1>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><div class=\"et_d4_element et_pb_section et_pb_section_1  et_pb_css_mix_blend_mode et_section_regular et_block_section\" >\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_d4_element et_pb_row et_pb_row_0  et_pb_css_mix_blend_mode et_block_row\">\n\t\t\t\t<div class=\"et_d4_element et_pb_column_1_3 et_pb_column et_pb_column_0  et_pb_css_mix_blend_mode et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_sidebar_0 et_pb_widget_area clearfix et_pb_widget_area_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div id=\"nav_menu-11\" class=\"et_pb_widget widget_nav_menu\"><h4 class=\"widgettitle\">Textos Cient\u00edficos<\/h4><div class=\"menu-textos-cientificos-container\"><ul id=\"menu-textos-cientificos\" class=\"menu\"><li id=\"menu-item-667\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-667\"><a href=\"https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/imunoglobulina-humana\/\">Imunoglobulina Humana<\/a><\/li>\n<li id=\"menu-item-666\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-666\"><a href=\"https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/cd40-l-e-neutropenia\/\">CD40 L e Neutropenia<\/a><\/li>\n<li id=\"menu-item-665\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-665\"><a href=\"https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/celulas-natural-killer-e-vigilancia-imunologica\/\">C\u00e9lulas Natural Killer e Vigil\u00e2ncia Imunol\u00f3gica<\/a><\/li>\n<\/ul><\/div><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div><div class=\"et_d4_element et_pb_column_2_3 et_pb_column et_pb_column_1  et_pb_css_mix_blend_mode et-last-child et_block_column\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_module et_d4_element et_pb_text et_pb_text_0  et_pb_text_align_left et_pb_bg_layout_light\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<div class=\"et_pb_text_inner\"><h3>DEFICI\u00caNCIA DE CD40 LIGANTE E NEUTROPENIA<\/h3>\n<h3>Estudo de caso - Paulinho<\/h3>\n\n\t\t<style>\n\t\t\t#gallery-1 {\n\t\t\t\tmargin: auto;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-item {\n\t\t\t\tfloat: left;\n\t\t\t\tmargin-top: 10px;\n\t\t\t\ttext-align: center;\n\t\t\t\twidth: 50%;\n\t\t\t}\n\t\t\t#gallery-1 img {\n\t\t\t\tborder: 2px solid #cfcfcf;\n\t\t\t}\n\t\t\t#gallery-1 .gallery-caption {\n\t\t\t\tmargin-left: 0;\n\t\t\t}\n\t\t\t\/* see gallery_shortcode() in wp-includes\/media.php *\/\n\t\t<\/style>\n\t\t<div id='gallery-1' class='gallery galleryid-0 gallery-columns-2 gallery-size-full'><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/cd40-l-e-neutropenia\/imunodeficiencias_paulinho\/'><img loading=\"lazy\" decoding=\"async\" width=\"243\" height=\"158\" src=\"https:\/\/dnareference.com.br\/clinica\/wp-content\/uploads\/sites\/3\/2016\/12\/Imunodeficiencias_Paulinho.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-464\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-1-464'>\n\t\t\t\tPaulinho passou por transplante de medula e foi curado\n\t\t\t\t<\/dd><\/dl><dl class='gallery-item'>\n\t\t\t<dt class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/dnareference.com.br\/clinica\/ensino\/textos-cientificos\/cd40-l-e-neutropenia\/imunodeficiencias_cd40\/'><img loading=\"lazy\" decoding=\"async\" width=\"243\" height=\"158\" src=\"https:\/\/dnareference.com.br\/clinica\/wp-content\/uploads\/sites\/3\/2016\/12\/Imunodeficiencias_CD40.jpg\" class=\"attachment-full size-full\" alt=\"\" aria-describedby=\"gallery-1-463\" \/><\/a>\n\t\t\t<\/dt>\n\t\t\t\t<dd class='wp-caption-text gallery-caption' id='gallery-1-463'>\n\t\t\t\tCD40L\n\t\t\t\t<\/dd><\/dl><br style=\"clear: both\" \/>\n\t\t<\/div>\n\n<p>Os pacientes com imunodefici\u00eancias prim\u00e1rias sofrem infec\u00e7\u00f5es por\u00a0n\u00e3o possu\u00edrem defesas imunol\u00f3gicas.\u00a0Muitos n\u00e3o produzem anticorpos, como o caso do Paulinho. Ele tinha uma altera\u00e7\u00e3o num gene que n\u00e3o permitia que as c\u00e9lulas produzissem seus anticorpos de defesa IgG e IgA. Logo, estava constantemente com infec\u00e7\u00f5es, o que acarretaria pouca sobrevida. O diagn\u00f3stico foi complexo, necessitando do sequenciamento de seu DNA e posterior transplante de medula \u00f3ssea. A nova medula com suas c\u00e9lulas tronco reconstitu\u00edram as defesas do Paulinho.\u00a0<strong>Paulinho est\u00e1 curado!<\/strong><\/p>\n<p>Os resultados iniciais dos exames eram:<\/p>\n<ul>\n<li>IgG:0<\/li>\n<li>IgA:0<\/li>\n<li>IgM 104<\/li>\n<li>Neutrop\u00eanico severo<\/li>\n<li>Aus\u00eancia c\u00e9lulas maduras na Medula \u00d3ssea<\/li>\n<li>Muta\u00e7\u00e3o no CD40L: (exon 5,A&gt;G)<\/li>\n<\/ul><\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":672,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-110","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages\/110","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/comments?post=110"}],"version-history":[{"count":5,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages\/110\/revisions"}],"predecessor-version":[{"id":683,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages\/110\/revisions\/683"}],"up":[{"embeddable":true,"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/pages\/672"}],"wp:attachment":[{"href":"https:\/\/dnareference.com.br\/clinica\/wp-json\/wp\/v2\/media?parent=110"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}